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Professor Lars Nielsen is leading the development of experimental and computational tools to analyse and design complex biological systems.
His expertise in metabolic modelling and flux analysis is available nowhere else in Australia and in few labs across the world. Professor Nielsen's studies of biological systems as diverse as bacteria, baker's yeast, sugarcane, insects and mammals has attracted industrial partnerships with companies including Dow, Metabolix, Amyris, LanzaTech, Boeing, Virgin Australia and GE. These metabolic engineering partnerships have focussed on developing new ways of producing aviation fuel, where can i buy a pandora charm bracelet various materials and bioactives (antibiotics, biopesticides, monoclonal antibodies). Professor Nielsen is also applying system analysis and design approaches to tissue engineering including novel strategies for generating microtissues for drug screening and using stem cells to produce red and white blood cells for transfusion. Professor Nielsen collaborates with some of the world's pre eminent metabolic engineers. A joint project with Prof Sang Yup Lee (KAIST, Korea) enabled several extended mutual visits to explore use of sugar for higher value products. A separate project focused on producing synthetic aviation fuel based on isoprenoids involves Professor Nielsen collaborating with global synthetic biotechnology company Amyris and leading isoprenoid metabolic engineer Professor Jay Keasling, from UC Berkeley. Professor Nielsen has secured $8million since 2006 from industry through research grants with US, European, Japanese, Korean, New Zealand and Australian companies. Systems and synthetic biology. Professor Nielsen is dedicated to both the advancement of bioengineering science and its application to specific problems. Using thermodynamic principles, novel approaches are developed for handling complex, transient dynamics in developing tissue as well as rational design of complex pathways. These novel approaches are used in the design of bioprocesses as diverse as the production of blood cells for transfusion and the production of industrial biopolymers. Memberships, patents and funding Professor Nielsen has been granted four patents two in stem cells and another two in metabolic engineering. He is on the Scientific Advisory Board of InSphero (2009 ), a Swiss company commercialising microtissue technology originating in the Nielsen laboratory. He is an editorial board member of ACS Synthetic Biology, Biotechnology and Bioengineering and Bioprocess and Biosystems Engineering. Professor Nielsen formed and chaired the 2005 CRC SIIB Industrial pandora charms special offers Biotechnology Panel to develop an industrial biotechnology strategy for the Australian sugar industry. He successfully lobbied for the inclusion of Industrial Biotechnology in the Queensland Biotechnology Strategic Plan 2005 2015. Since then he has served as expert advisor to government, research bodies, domestic and major international companies such as Dow Chemical, DuPont and GS Caltex. In the past decade, he has been part of successful research grant applications totalling $56 million, with $31.2 million for his own systems and synthetic biology group at AIBN. Journal Article: Arginine deiminase pathway provides ATP and boosts growth of the gas fermenting acetogen Clostridium autoethanogenum Valgepea, Kaspar, Loi, Kim Q., Behrendorff, James B., Lemgruber, Renato de S. P., Plan, Manuel, Hodson, Mark P., Koepke, Michael, Nielsen, Lars K. and Marcellin, Esteban (2017) Arginine deiminase pathway provides ATP and boosts growth of the gas fermenting acetogen Clostridium autoethanogenum. Journal Article: Luna Flores, Carlos H., Nielsen, Lars K. and Marcellin, Estaban (2017).4 3:. doi:10.1128/genomeA.00248 16 Journal Article: Coupling gene regulatory patterns to bioprocess premier designs jewelry conditions to optimize synthetic metabolic modules for improved sesquiterpene production in yeast Peng, Bingyin, Plan, Manuel R., Carpenter, Alexander, Nielsen, Lars K. and Vickers, Claudia E. O. and Nielsen, Lars K. (2016).. In Michael A. Borowitzka, John Beardall and John A. Raven (Ed.), Vickers, Claudia E., Behrendorff, James B. Y. H., Bongers, Mareike, Brennan, Timothy C. R., Bruschi, Michele and Nielsen, Lars K. (2015).. In Birgit Kamm (Ed.),Customization of 13C MFA Strategy According to Cell Culture System Quek, Lake Ee and Nielsen, Lars K. (2014). Customization of 13C MFA Strategy According to Cell Culture System. In Jens O. Kromer, Lars K. Nielsen and Lars M. Blank (Ed.), Metabolic Flux Analysis: Methods and Protocols (pp. 81 90) New pandora bead necklace York, NY United States: Humana Press. doi:10.1007/978 1 4939 1170 7_5 NExT: integration of thermodynamic constraints and metabolomics data into a metabolic network Mart Veronica Sof and Nielsen, LK (2014). NExT: integration of thermodynamic constraints and metabolomics data into a metabolic network. In Jens O. Kromer, Lars K. Nielsen and Lars M. Blank (Ed.), Metabolic Flux Analysis: Methods and Protocols (pp.
65 78) New York, NY United States: Humana Press. doi:10.1007/978 1 4939 1170 7_4.
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