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Renal effects of targeted anticancer therapies The use of novel targeted anticancer agents has led to overall improvement in the prognosis of many patients affected by various malignancies, but has also been associated with an increased risk of poorly characterized toxic effects to different organs, including the kidneys.
The high prevalence of kidney impairment in the general population complicates the issue further. Nephrologists most frequently work with patients with cancer when they are asked to investigate kidney function to assess the need for dose adjustments in anticancer therapy. A thorough knowledge of the renal safety profile of novel life prolonging anticancer therapies, specific features of their metabolism, and pharmacokinetic and pharmacodynamic properties (under normal circumstances as well as in the setting of renal replacement therapy) is, therefore, necessary to preserve kidney function as far as possible and places that sell pandora bracelets to ensure optimum treatment. In this Review we summarize the present knowledge of renal toxic effects from novel targeted anticancer agents and discuss whether jewellery australia the management of patients treatment needs to be modified. San Matteo University Hospital Foundation in Pavia, and Adjunct Professor of Medical Oncology at the University of Pavia, Pavia, Italy, and is President of the Italian Group of Nephro Oncology and a member of the joint Italian Association of Medical Oncology/Italian Society of Nephrology Working Group on Nephro Oncology. His main clinical and scientific interests are the development of novel anticancer targeted treatments, especially (but not exclusively) in kidney cancer. She is also a member of the joint Italian Association of Medical Oncology/Italian Society price pandora bracelet of Nephrology Working Group on Nephro Oncology and the Italian Group of Nephro Oncology. San Matteo University Hospital Foundation in Pavia, Italy.
He is member of the Italian Society of Oncology, European Society of Medical Oncology and the American Society of Clinical Oncology. He has also been a co investigator or the principal investigator in several clinical trials with targeted agents conducted in the field of medical oncology. He is also Adjunct Professor of Nephrology at the University of Pavia, Pavia, Italy, and a member of the Italian Society of pendant bracelets pandora Nephrology, European Dialysis and Transplant Association, American Society of Nephrology and the International Society of Nephrology.
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